paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth inhibition study in nude mice implanted cozaar powered by vbulletin version with human colon cancer cells the mean tumor volume from each group was blotted against the number of days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized cozaar powered by vbulletin version for paclitaxel, was tripled in all cozaar powered by vbulletin version treatment groups empty dqasomes do not show any impact on tumor growth, cozaar powered by vbulletin version paclitaxelloaded dqasomes with paclitaxel and dequalinium cozaar powered by vbulletin version concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately half of that in all controls although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial description in , dqasomes and dqasomelike vesicles have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within cozaar powered by vbulletin version living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions and for his strong and continuous support of my work i also would like to sincerely thank my graduate students, gerard cozaar powered by vbulletin version dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has cozaar powered by vbulletin version made the writing of this chapter cozaar powered by vbulletin version possible i am obliged to the muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern cozaar powered by vbulletin version university boston, ma for the financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and cozaar powered by vbulletin version hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and murphy mp delivery of bioactive molecules to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria cozaar powered by vbulletin version as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr syst weissig v, cheng sm and cozaar powered by vbulletin version dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian mitochondria in living cells exp opin drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting of low molecular weight drugs to mammalian mitochondria drug des rev de cozaar powered by vbulletin version rosa m, gambacorta a and gliozi a celebrex dosages structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol cozaar powered by vbulletin version biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control cozaar powered by vbulletin version rel bioact mater weissig v, lizano � and torchilin vp a micellar delivery system for dequalinium � a cozaar powered by vbulletin version lipophilic cationic drug with anticarcinoma activity j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy cozaar powered by vbulletin version for mitochondrial dna defects is it possible?